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2012, Rawal Medical Journal
injuries. Frontal lobes (31.17%) and temporal To analyze characteristics of patients with bomb lobes (24.67%) of the brain were commonly blast head injuries in a tertiary care hospital of affected. The common complications were Khyber Pukhtoonkhwa, Pakistan. neurodeficit (52%), wound infection (13.6%), Patients and Methods cerebrospinal fluid leak (9.1%), epilepsy (5.8%) This observational study was conducted at the and post traumatic hydrocephalous (3.3%). department of Neurosurgery, Lady Reading Mortality rate was 11.7%. Hospital, Peshawar, Pakistan from January 2009 Conclusion to December 2010. We included all the patients Significant number of hospitalized patients with bomb blast head injuries who were exposed to explosion had head injuries. Young hospitalized, irrespective of their age and gender, males were mainly affected. Frontal and temporal and excluded those patients who died before lobes of the brain were the common sites of injury. hospitalization. Mortality rate in the hospitalized head injured Results patients was 11.7%. The common complications Out of a total of 2052 bomb blast victims treated in in surviving patients were neurodeficit and wound Lady Reading Hospital, 154 patients had head infections. (Rawal Med J 2012;37:417-420). trauma. Out of these 154 patients, 131 (85.1%) Keywords were male with the age range from 2 months to 70 Bomb blast injuries, warfare injuries, years. Common age groups affected were 2nd traumatic brain injury, penetrating brain and 3rd decades (24% and 29% respectively) of injuries. life. 14 % of these patients had severe head
Journal of Emergencies, Trauma, and Shock, 2010
Explosions and bombings are the most common deliberate cause of disasters with large numbers of casualties. Despite this fact, disaster medical response training has traditionally focused on the management of injuries following natural disasters and terrorist attacks with biological, chemical, and nuclear agents. The following article is a clinical primer for physicians regarding traumatic brain injury (TBI) caused by explosions and bombings. The history, physics, and treatment of TBI are outlined.
Journal of Armed Forces Medical College, Bangladesh, 2020
Introduction: A traumatic brain injury (TBI) is an injury to the brain caused by an impact to the head. TBI represents a huge global medical and public health problem across all ages and in both civilian and military populations. TBI is characterized by great heterogeneity in terms of etiology, mechanism, pathology, severity and treatment with widely varying outcomes. Objective: To determine the pattern and outcome of traumatic brain injuries in victims reported to emergency and casualty (E&C) department following intensive care with or without surgical intervention. Materials and Methods: This prospective type of observational study was conducted at Neurosurgery department of Combined Military Hospital, Dhaka from October 2013 to March 2017. A total of 675 head injury patients with TBI were assessed with gender, age, cause and type of trauma, GCS on admission, associated other injuries, time lapsed from trauma to hospitalization and care given. The outcome was measured after 72 hou...
Journal of Experimental Neuroscience
Traumatic brain injury (TBI) is a well-known consequence of participation in activities such as military combat or collision sports. But the wide variability in eliciting circumstances and injury severities makes the study of TBI as a uniform disease state impossible. Military Service members are under additional, unique threats such as exposure to explosive blast and its unique effects on the body. This review is aimed toward TBI researchers, as it covers important concepts and considerations for studying blast-induced head trauma. These include the comparability of blast-induced head trauma to other mechanisms of TBI, whether blast overpressure induces measureable biomarkers, and whether a biodosimeter can link blast exposure to health outcomes, using acute radiation exposure as a corollary. This examination is contextualized by the understanding of concussive events and their psychological effects throughout the past century’s wars, as well as the variables that predict sustainin...
The American surgeon, 2011
Brief Reports should be submitted online to www.editorialmanager.com/ amsurg. (See details online under ''Instructions for Authors''.) They should be no more than 4 double-spaced pages with no Abstract or sub-headings, with a maximum of four (4) references. If figures are included, they should be limited to two (2). The cost of printing color figures is the responsibility of the author.
Brain injury, 2018
To assess the demographics, causes, treatment and outcome of traumatic brain injury (TBI) in Tehran, Iran. This retrospective study was conducted in a major trauma centre in south of Tehran using clinical data registry of 3818 traumatic patients who admitted to the hospital from 2009 to 2013. The main factors measured were the external cause of trauma, the type of TBI, and treatment outcome. The highest rate of TBIs occurred in age categories 21‒30 (31.5%), 31‒40 (19.2%) and 41‒50 (12.3%) years. Transport accidents were the most common cause of TBIs (2915 cases, 76.4%). The most frequent types of head injuries were subarachnoid (1676, 43.9%) subdural (1140, 29.8%), and epidural haemorrhage (974, 25.5%). A binomial logistic regression showed that mortality (612 patients, 16%) was significantly associated with the external cause of TBI, the type of main and additional head injuries, cervical spine injury, intra-abdominal organ injury, having a brain or abdominal surgery, and length of...
Journal of Cerebral Blood Flow & Metabolism, 2010
This review considers the pathobiology of non-impact blast-induced neurotrauma (BINT). The pathobiology of traumatic brain injury (TBI) has been historically studied in experimental models mimicking features seen in the civilian population. These brain injuries are characterized by primary damage to both gray and white matter and subsequent evolution of secondary pathogenic events at the cellular, biochemical, and molecular levels, which collectively mediate widespread neurodegeneration. An emerging field of research addresses brain injuries related to the military, in particular blast-induced brain injuries. What is clear from the effort to date is that the pathobiology of military TBIs, particularly BINT, has characteristics not seen in other types of brain injury, despite similar secondary injury cascades. The pathobiology of primary BINT is extremely complex. It comprises systemic, local, and cerebral responses interacting and often occurring in parallel. Activation of the autonomous nervous system, sudden pressure-increase in vital organs such as lungs and liver, and activation of neuroendocrine-immune system are among the most important mechanisms significantly contributing to molecular changes and cascading injury mechanisms in the brain.
The Lancet Neurology, 2013
A bomb blast may cause the full severity range of traumatic brain injury (TBI), from mild concussion to severe, penetrating injury. The pathophysiology of blast-related TBI is distinctive, with injury magnitude dependent on several factors, including blast energy and distance from the blast epicentre. The prevalence of blast-related mild TBI in modern war zones has varied widely, but detection is optimised by battlefi eld assessment of concussion and followup screening of all personnel with potential concussive events. There is substantial overlap between post-concussive syndrome and post-traumatic stress disorder, and blast-related mild TBI seems to increase the risk of post-traumatic stress disorder. Post-concussive syndrome, post-traumatic stress disorder, and chronic pain are a clinical triad in this patient group. Persistent impairment after blast-related mild TBI might be largely attributable to psychological factors, although a causative link between repeated mild TBIs caused by blasts and chronic traumatic encephalopathy has not been established. The application of advanced neuroimaging and the identifi cation of specifi c molecular biomarkers in serum for diagnosis and prognosis are rapidly advancing, and might help to further categorise these injuries.
Journal of National Institute of Neurosciences Bangladesh, 2023
Background: Traumatic brain injury is a significant public health problem. Objective: This study was aimed to clinical characteristics of traumatic brain injury patients by collection of detailed data on demography, clinical, injury patterns, co-morbidities, laboratory findings, and outcome of mild and moderate TBI.
Journal of Evidence Based Medicine and Healthcare, 2019
BACKGROUND Traumatic brain injury is a major public health problem in India resulting in deaths, injuries and disabilities of young and productive people of our society. With increasing pace of growth, urbanization, motorization, India is going to witness an alarming epidemic of trauma victims in near future. Growing incidence of trauma in MP is a national concern at present. It was observed that approx. 50% of total head injury cases fell in the category of moderate or severe head injury. The objectives of this study were-1. to prospectively evaluate the patients of moderate and severe traumatic brain injury, admitted in Department of Surgery, Maharaja Yashwantrao Hospital, Indore, during the one-year study period (March 2015-March 2016). 2. analysis of pattern of injuries, their cause and contributing factors like alcohol and outcome in terms of hospital stay and mortality. MATERIALS AND METHODS This prospective study was conducted at Maharaja Yashwant Rao Hospital, Indore during the period of one year from March 2015 till March 2016. All consecutive patients of moderate and severe traumatic brain injury (GCS <12/15
Archives of Trauma Research
Original Article intROductiOn Traumatic brain injury (TBI) is one of the major health and socioeconomic problems in Iran and around the world. [1,2] According to the World Health Organization, TBI is the third leading cause of death and disability in the world in 2020. [3] About 37% of all deaths following injuries are caused by TBI. [4] Each year about 50,000 deaths after TBI are reported in the United States. [5] In recent years, the number of people with TBI has increased steadily in developed and developing countries. [6] In Iran, head-and-neck trauma is one of the most common types of injuries, and the most common mechanism is motor vehicle accidents. [7] TBI is more common in the middle-aged, followed by teenagers and the elderly. [6] However, with the increase in the age of the population, the proportion of the elderly with TBI has increased compared to young patients. [8] Mortality and morbidity after TBI vary by age. The mortality rate in Background and Objectives: Traumatic brain injury (TBI) is one of the major health and socioeconomic problems in the world. How clinicopathological features of TBI differ by age is unclear. The present study evaluated the epidemiology of TBI and identified any variable that differs among pediatric, middle-aged, and elderly patients. Methods: The descriptive cross-sectional study was conducted on patients with TBI from April 2019 to April 2021. The study population consisted of all patients with TBI who were admitted to the Emergency Department. The inclusion criteria were all TBI patients who were a candidate for head computed tomography (CT) scans. The patients' clinicopathological parameters were recorded. Results: Among 3513 patients with TBI who underwent CT scans, 212 patients died (6.0%). The mean age of subjects was 30.67 ± 19.42, and 69.2% of the patients (2430 cases) were male. Motor vehicle accidents (48.4%) were the most prevalent mechanisms of injury. Intracranial lesions were seen on the head CT scan in 509 (14.5%) patients. The highest mortality rate was shown in elderly patients and the lowest in children (P < 0.001). Falls were the most common mechanism of injury in the elderly subjects (65.2%), while motor vehicle accidents were the most common in the children and middle-aged groups (40.9% and 54.0%). The incidence of intracranial lesions and moderate-to-severe head injuries was significantly higher in the elderly subjects (P < 0.001). Subdural hematoma and subarachnoid hemorrhage were the most common CT findings in elderly patients (13.3% and 11.3%). Brain contusion and skull fracture were the most common findings in the children (6.0% and 4.3%). Conclusions: The present study found that the clinicopathological parameters were significantly different among children, middle-aged patients, and elderly patients.
Hospital Practices and Research, 2021
Background: Traumatic brain injury (TBI) is the damage to brain tissue and disruption of the brain function caused by an external mechanical force as evidenced by documented medical records. Objectives: The study aimed to estimate the prevalence of TBI through age-groups, severity, and mechanism of TBI. Methods: This cross-sectional study contained all TBI patients who were admitted at the main level one trauma center hospital located in southeastern Iran. Results: The number of reported patients was 445 young and old adults with TBI. In total, the mean age of the patients was 32.35 ranging from 17 to >80 years. Of the studied patients 361 (81.1%) were male and 84 (18.9%) were women. The most common principal severity of TBI among patients aged 20–29 years was moderate. This corresponds with the age groups that are known to be at higher risk for three levels of TBI. Car accident multiple trauma and head trauma show severity of TBI in both genders. Conclusion: The research findings determined the lack of ignoring the traffic control system in southeastern Iran that was the main cause of the injury; consequently, the focus of all essentials in traffic management should be considered for this problem. It must be noted that the incidence of TBI is necessary as there remains no cure for mild-to-severe TBI. As the evidence for effectiveness and specific treatment is limited, it must be subjected to demanding research. Keywords: Traumatic Brain Injuries, Trauma Center, Epidemiology, Injury Characteristics
مجلة جامعة الملك عبدالعزيز-العلوم الطبية
Traumatic brain injury is a common problem in society leading to morbidity and mortality. This study describes pattern of traumatic brain injury at King Abdulaziz University Hospital, and identify the demographic and clinical factors affected in the survivors' hospital length of stay. A retrospective study performed in January 2003 till January 2009. The incidence of traumatic brain injury requiring admission in relation to annual emergency room is 75/100,000 patients; mean age is 9.5 ± 4 years with ~81% of injuries occurring at < 30 years. Severe traumatic brain injury accounts for 15.1% of cases, whereas moderate traumatic brain injury accounts for 10.4% and mild traumatic brain injury accounts for 74.5%. Mechanisms of injuries: 46.5%, falling from a height, 26.7% motor vehicle collisions, 10.4% pedestrian-vehicle collisions and 10.4% assault victims. Factors affecting the hospital length of stay: Admission Glasgow Coma Scale (p < 0.001), loss of consciousness p < 0.001, presence of motor weakness p < 0.001, female gender p < 0.03, patients' age p < 0.001 and the nationality p < 0.001. Characteristics of traumatic brain injury: Young age, the mechanism of injury (mainly falls) and type of injury (mainly concussion). Tentatively, the patients' length of stay is predicted on the demographic and clinical data.
Molecules (Basel, Switzerland), 2018
Traumatic brain injury (TBI) is one of the most frequent causes of combat casualties in Operations Iraqi Freedom (OIF), Enduring Freedom (OEF), and New Dawn (OND). Although less common than combat-related blast exposure, there have been significant numbers of blast injuries in civilian populations in the United States. Current United States Department of Defense (DoD) ICD-9 derived diagnoses of TBI in the DoD Health Care System show that, for 2016, severe and moderate TBIs accounted for just 0.7% and 12.9%, respectively, of the total of 13,634 brain injuries, while mild TBIs (mTBIs) accounted for 86% of the total. Although there is a report that there are differences in the frequency of long-term complications in mTBI between blast and non-blast TBIs, clinical presentation is classified by severity score rather than mechanism because severity scoring is associated with prognosis in clinical practice. Blast TBI (bTBI) is unique in its pathology and mechanism, but there is no treatmen...
Brain Injury, 2011
Primary objective: The eruption of Al-Aqsa Intifada created a war situation in Palestine, increasing the number of firearms injuries caused by occupying Israeli forces as well as disabling head injuries. No data were available to the Palestinian Ministry of Health and other health organizations on traumatic brain injury (TBI) in Palestine. This study, therefore, sought to determine the causes and outcomes of TBI in patients who were admitted to three hospitals in Nablus, Palestine. Research design: Retrospective review of medical records and contacts with patients and/or caregivers. Methods and procedures: The medical records of patients who were diagnosed with TBI (n ¼ 312) and admitted to any one of the three hospitals in 2006 and 2007 were reviewed. Data were also obtained from follow-up home visits and telephone calls with consenting patients and/or caregivers. Main outcomes and results: The major causes of TBI were assault (33%), falls (32.1%), road traffic crashes (29.8%) and impacts from heavy objects (3.2%). Gunshot wounds are a major cause of head injury in Palestine. Conclusions: The study shows that assault with firearms is the most frequent cause of TBI in this population and that patients with head injuries due to assault have poorer outcomes at discharge than those injured in other ways.
Journal of Neurosciences in Rural Practice, 2016
Traumatic brain injury (TBI), a significant public health problem, is a leading cause of disability and mortality in all regions of the globe despite advancement in prevention and treatments. Its global incidence is rising, and it is predicted to surpass many diseases as a major cause of death and disability by the year 2020. [1] TBI is the main cause of one-third to one-half of all trauma deaths and the leading cause of disability in people under forty, severely disabling 15-20/100,000 populations per year. [2] The World Health Organization estimates that almost 90% of deaths due to injuries occur in low-and middle-income countries (LAMICs), where 85% of population live, and this situation will continue to represent an important global health problem in the upcoming years. [3,4] TBI is a leading cause of mortality, morbidity, disability, and socioeconomic losses in India as well. It is estimated that nearly 1.5-2 million persons are injured, and 1 million die every year in India. [5] India and other developing countries are facing the major challenges of prevention, prehospital care, and rehabilitation in their
EAS Journal of Radiology and Imaging Technology, 2021
Background: Traumatic brain injury and its implications lead to huge public health issues. Annually, TBI affects approximately 50 million individuals all around the world. Head injury is the leading neurological reason for despondency and fatality, particularly influencing the youngsters. 85% to 90% are mild or moderate TBI. Objective: To find prevalence of traumatic brain injuries on computed tomography and that of severity classification from mild to severe grade. Material and Methods: 100 patients with history of head trauma were evaluated in this study, which came to emergency department of Public sector. GCS was taken and all were referred to CT. Noncontrast CT of brain was performed with slice thickness of 3mm from skull base to vertex. And analysis was done using (SPSS) Statistical Package for the Social Sciences version 21. Results: Of 100 TBI patients, men composed 66% and women 34%. Falls (38%), violence (2%) and other causes (5%) all collectively cause fewer traumas than RTA (55%) specifically in patients of age group 16-26 years. Different traumatic brain injuries were noted including EDH (22%), IPH (23%), SAH (9%), SDH (27%), Contusion (4%) and infarction (15%). Noteworthy, most of the brain injuries were observed as mild TBI in 65% of cases accounting for more than moderate (21%) and severe TBI (14%). Conclusion: The study concludes that 65% of patients who acquired head trauma had mild TBI while remaining 21% and 14% consumed moderate and severe TBI respectively. Subdural and intraparenchymal hemorrhages are most frequent type of diagnosis in TBI.
The Lancet Neurology, 2008
Traumatic brain injury (TBI) is a major health and socioeconomic problem that aff ects all societies. In recent years, patterns of injury have been changing, with more injuries, particularly contusions, occurring in older patients. Blast injuries have been identifi ed as a novel entity with specifi c characteristics. Traditional approaches to the classifi cation of clinical severity are the subject of debate owing to the widespread policy of early sedation and ventilation in more severely injured patients, and are being supplemented with structural and functional neuroimaging. Basic science research has greatly advanced our knowledge of the mechanisms involved in secondary damage, creating opportunities for medical intervention and targeted therapies; however, translating this research into patient benefi t remains a challenge. Clinical management has become much more structured and evidence based since the publication of guidelines covering many aspects of care. In this Review, we summarise new developments and current knowledge and controversies, focusing on moderate and severe TBI in adults. Suggestions are provided for the way forward, with an emphasis on epidemiological monitoring, trauma organisation, and approaches to management.
Journal of Neurotrauma, 2011
Many soldiers returning from the current conflicts in Iraq and Afghanistan have had at least one exposure to an explosive event and a significant number have symptoms consistent with traumatic brain injury. Although blast injury risk functions have been determined and validated for pulmonary injury, there is little information on the blast levels necessary to cause blast brain injury. Anesthetized male New Zealand White rabbits were exposed to varying levels of shock tube blast exposure focused on the head, while their thoraces were protected. The specimens were euthanized and evaluated when the blast resulted in respiratory arrest that was non-responsive to resuscitation or at 4 h post-exposure. Injury was evaluated by gross examination and histological evaluation. The fatality data from brain injury were then analyzed using Fisher's exact test to determine a brain fatality risk function. Greater blast intensity was associated with post-blast apnea and the need for mechanical ventilation. Gross examination revealed multifocal subdural hemorrhages, most often near the brainstem, at more intense levels of exposure. Histological evaluation revealed subdural and subarachnoid hemorrhages in the nonresponsive respiratory-arrested specimens. A fatality risk function from blast exposure to the head was determined for the rabbit specimens with an LD 50 at a peak overpressure of 750 kPa. Scaling techniques were used to predict injury risk at other blast overpressure/duration combinations. The fatality risk function showed that the blast level needed to cause fatality from an overpressure wave exposure to the head was greater than the peak overpressure needed to cause fatality from pulmonary injury. This risk function can be used to guide future research for blast brain injury by providing a realistic fatality risk to guide the design of protection or to evaluate injury.
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