Characterization of Single Layer Wound Healing Dressing by Using Different Techniques

Journal of the Mechanical Behavior of Biomedical Materials, 2011

Wound healing

There is endless and growing demand on a novel and innovative wound dressings, which except basic protective performance accelerate the process of wounds healing and/or replace the patient skin function. The studies on the new wound dressings result from the need of the quick and effective treatment of wounds, such as: having no tendency to heal, posttraumatic wounds, scalding wounds, ulcerations or bedsores. Chitosan is a biopolymer originated from chitin by N-acetylation. Due to the special behavior, such as: biological activity, it is linked to polymers having several and multifunctional applications, especially for designing of medical devices. The aim of the research was to evaluate the comprehensive performance of several kinds of chitosan prototypes of innovative wound dressings made of various usable form of chitosan. The evaluation of mentioned prototypes of wound dressing was carried out using the guidelines from series of PN-EN 13726 Standards harmonized with UE Directive 93/42/EEC and 2007/47/WE for medical devices.

The new implemented wound dressings should meet several requirements connected with the clinical safety and performance. The series of PN-EN 13726 Standards describes the tests methods for the verification the most important parameters related to mentioned performance and safety of a new designed wound dressing being the base for the risk analysis (according to PN-EN ISO 14971:2009 Standard). The aim of the research was to evaluate the behavior of several types of new designed prototypes of innovative wound dressings made of various form of chitosan (such as: foams, films, etc.). The behavior of studied chitosan wound dressings was evaluated before and after of accelerated aging according to ASTM F 1980ASTM F -07:2002 to establish the effect of the wound dressings storing conditions. The presented study is a continuation of earlier research.

Wound care dressings aim to restore the milieu required for skin regeneration and to protect the wound from environmental thre ats and penetration of bacteria. Any single type of wound dressing can not address the need and management of all types of wound s. The availability of different types of wound dressings and research for newer type of wound dressing has increased in the la st decade. This review discusses the common and advanced wound management dressings, their key advantages and shortcomings. It also discusses the need for dressin gs with their properties in wound management. The definition and classification of wounds together with the different stages of wound healing are also briefly described. In addition to that this article also compiles the list of wound care product available in the market.

The important parameters of an “ideal wound dressing” include its ability to absorb exudates and toxic components from the wounds surface, maintain a high humidity at the wound/dressing interface, allow gaseous exchange, provide thermal insulation, protect the wound from bacterial penetration,be nontoxic and be removed easily without trauma to the wound [1]. Criteria that were added later included that the material should have acceptable handling qualities (resistance to tear and disintegration when wet or dry), and be comformable and be sterilizable [2]. Many of the newer dressings are designed to create a moist wound healing environment which allows the wound fluids to remain in contact with wound. The concept of moist wound healing has been around since the 1960s,[3] but only recently has become a more accepted treatment approach in the veterinary community [4].A moist wound free of infection provides an environment rich in white blood cells, enzymes, cytokines and growth factors...

International Surgery Journal, 2016

Background: The dressing of wounds is an old art and has undergone a wide variety of changes from ancient herbal dressing to modern dressing materials. The main aim was always to heal the wounds. Wounds and their management are fundamental in the practice of surgery. The prevalence of leg ulceration is approximately 1% to 2%, and is slightly higher in the older adult population. The main aim of the study was to compare the newer dressing materials versus the conventional dressing materials in terms of various factors responsible for wound healing. Methods: A total of one hundred patients admitted in surgery ward were allotted into two groupsconventional dressing materials (regime A) and newer dressing materials (regime B) on random basis. The patients were assessed on daily basis in both test and control groups with parameters like ulcer size, rate of granulation tissue formation, time required for removal of slough and rate of wound healing. Results: Out of 100 cases studied, maximum numbers of patients were in age group 51 to 60 years (23%). With use of Regime A we have noticed that healing stage in 1 patient was within 7 days, 8 patients between 8-14 days, 13 patients between 15-21 days and 28 patients between 22-30 days. With use of Regime B we have noticed healing stage in 4 patients was within 7 days, 13 patients between 8-14 days, 19 patients between 15-21 days and 14 patients between 22-30 days. Conclusions: As per study carried out we would conclude that newer dressing materials are more efficient as compared to conventional dressing materials in all stages of ulcer healing even though there is slight compromise in its availability.

The variety of wound types has resulted in a wide range of wound dressings with new products frequently introduced to target different aspects of the wound healing process. The ideal dressing should achieve rapid healing at reasonable cost with minimal inconvenience to the patient. This article offers a review of the common wound management dressings and emerging technologies for achieving improved wound healing. Italso reviews many of the dressings and novel polymers used for the delivery of drugs toacute, chronic and other types of wound. These include hydrocolloids, alginates, hydrogels, polyurethane, collagen, chitosan, pectin and hyaluronic acid. There is also a brief section on the use of biological polymers as tissue engineered scaffolds and skin grafts

Journal of biomaterials applications, 2015

The physical and biological assessments of the innovative bilayered wound dressing made of silk and gelatin that we have developed previously were performed to evaluate its efficacy for clinical applications. The absorption ability and dehydration rate of the dressing were assessed using the split-thickness skin graft and leg ulcer wound bed models. The bioactivities of the bilayered wound dressing were evaluated. The bilayered dressing showed continuous absorption rate of wound exudate, providing the suitability for the wound with extended inflammation phase. The dehydration rate of the bilayered dressing was comparable to the commercially available dressing of which the moisture maintenance capability is claimed. The bilayered dressing showed good conformability, as can be seen by the homogeneous distribution pattern of bromophenol blue absorbed. In terms of biological activities, the bilayered dressing was less toxic to skin cells than the commercially available dressing. The bil...

2015

CRISTINA-DELIA NECHIFOR1, CARMEN-BEATRICE ZELINSCHI2, DANA-ORTANSA DOROHOI3* 1 “Gheorghe Asachi” Technical University.of Iasi, Department of Physics, Machine Manufacturing and Industrial Management Faculty, 67 Dimitrie Mangeron Bvd, 700050, Iasi, Romania 2“Vasile Adamachi” College for Agriculture and Food Industry, 41 Mihail Sadoveanu Alley, Iasi, Romania. 3 ”Alexandru Ioan Cuza” University, Faculty of Physics, 11 Carol I Bvd., 700506, Iasi, Romania,

Pharmaceutical patent analyst, 2013

Wound management covers all aspects of patient care from initial injury, treatment of infection, fluid loss, tissue regeneration, wound closure to final scar formation and remodeling. There are many wound-care products available including simple protective layers, hydrogels, metal ion-impregnated dressings and artificial skin substitutes, which facilitate surface closure. This review examines recent developments in wound dressings, biomaterials and devices. Particular attention is focused on the design and manufacture of hydrogel-based dressings, their polymeric constituents and chemical modification. Finally, topical negative pressure and hyperbaric oxygen therapy are considered. Current wound-management strategies can be expensive, time consuming and labor intensive. Progress in the multidisciplinary arena of wound care will address these issues and be of immense benefit to patients, by improving both clinical outcomes and their quality of life.